Not recommended appointment fluoxymesterone sulpiride pregnant, except when the doctor to weigh the risks and benefits for the pregnant woman and the fetus, decides that the use of the drug is needed.
It is not recommended the appointment of sulpiride in combination with: alcohol, levodopa, drugs capable of cause ventricular arrhythmias such as «torsade des pointes»: means of arrhythmic class Ia (quinidine, gidrohinidin, disopyramide) and class III (amiodarone, sotalol, dofetilide, Ibutilide); some antipsychotic drugs (thioridazine, chlorpromazine, Levomepromazine, trifluoperazine, tsiamemazin, amisulpride, tiaprid, pimozide, haloperidol, droperidol); other drugs, such as: bepridil, cisapride, difemanil, intravenous erythromycin, mizolastine, intravenous vincamine, halofantrine, pentamidine, sparfloxacin, moxifloxacin, etc.
Due to the presence of lactose drug sulpiride is contraindicated in congenital deficiency of lactase, lactose intolerance , glucose-galactose malabsorption.
Care should be exercised in the appointment of sulpiride in patients with renal and / or hepatic insufficiency, neuroleptic malignant syndrome (NMS), a history of epilepsy or seizures in history, severe heart disease, hypertension, syndrome / Parkinson’s disease, dysmenorrhea, in old age.
Pregnancy and lactation
Animal experiments have not revealed teratogenic effects. A small number of women taking during pregnancy low dose sulpiride (approximately 200 mg / day), there was no teratogenic effect. With regard to the use of higher doses sulpiride data are not available. There is also the potential effect of these neuroleptic drugs taken during pregnancy on the development of the fetal brain. Consequently,. As a precaution, sulpiride preferably not used during pregnancy. However, fluoxymesterone when using this drug during pregnancy is recommended whenever possible to limit the dose and duration of treatment. Neonates whose mothers have received long-term treatment with high doses of neuroleptics, rarely observed gastrointestinal symptoms (bloating, etc.) associated with the m-anticholinergic effect of some drugs, especially in combination with antiparkinsonian agents and extrapyramidal syndrome.
When long-term treatment of the mother or the use of high doses, as well as in the case of the appointment of the drug shortly before delivery, reasonable control over the activity of the nervous system of both mother and newborn.
The drug passes into breast milk, so you should stop taking the drug during breastfeeding.
The dose and method of administration
Tablets are taken 1-3 times a day, drinking a small amount of liquid, regardless of the meal. It is not recommended to take the drug in the second half of the day (after 16 hours) due to the increased level of activity. The goal of therapy – to reach a minimum effective dose. Tablets 200 mg Acute and chronic schizophrenia, acute delirium psychosis, depression: the daily dose is 200 mg to 1000 mg, divided into several times. Tablets 50 mg neuroses and anxiety in adults: the fluoxymesterone daily dose of . from 50 to 150 mg for 4 weeks maximum Heavy behavioral disorders in children over 6 years: the daily dose is from 5 to 10 mg / kg body weight.